Dr Jean DONADIEU


Contact Information

Dr Jean DONADIEU
Address:Registre des neutropénies - Centre de référence des neutropénies chroniques  Service d'Hémato-Oncologie Pédiatrique
Hopital Trousseau
26 avenue du Dr Netter F 75012 Paris France
www.neutropenies.fr

Email :  jean.donadieu@trs.aphp.fr 
Tel:       33 1 44 73 53 14 / dect 33 1 71 73 82 66
Fax:      33 1 44 73 65 73


Current research interests

In addition to my clinical works as a pediatrician in a pediatric hemato oncology unit, my research aims to describe the various subtype of neutropenia (cause/ natural history), to develop new therapeutic approaches, to assess the risk factors of leukemic transformation, to approach neutropenia as an epidemiological issue.  I manage the French chronic registry, founded in 1994, which first enroll all patients with chronic neutropenia in france, which collect follow up data. This structure is a strong help to foster several biological researches in the field of CN: epidemiology, genetic, somatic mutations leading to leukemia.


Clinical Expertise related to EuNet-INNOCHRON

  • Epidemiology and registry
  • Natural history of neutropenia and classification
  • Coordination of researches

Laboratory Epertise related to EuNet-INNOCHRON

  • A biobank is organized in my institution. But our networks several partners in france www.neutropenie.fr: 
  • Auto antibodies: 2 teams in france, one in Creteil (close to paris) Dr Croisille and one in Nantes Dr Audrain.
  • Medical genetic: Pitié Salpétriere Hospital
  • Somatic mutation: Saint Antoine Hematological Lab
  • Researches
  • Genetic: Pitié Salpétriere Hospital
  • WHIM team: Clamart (F Bachelerie) and St Louis (K Balabanian)
  • Ribosomopathy. Imagine foundation (P Revy)
  • Myelopoeisis : IGR (I Plo)

Recent publications related to Eunet-INNOCHRON

  • Bellanne-Chantelot C, Schmaltz-Panneau B, Marty C et al. Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. Blood 2018; 132(12):  1318-1331.
  • Donadieu J, Fenneteau O, Beaupain B et al. Classification of and risk factors for hematologic complications in a French national cohort of 102 patients with Shwachman-Diamond syndrome. Haematologica 2012; 97(9):  1312-1319.
  • Donadieu J, Beaupain B, Fenneteau O, Bellanne-Chantelot C. Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history. Br.J.Haematol. 2017; 179(4):  557-574.
  • Donadieu J, Lamant M, Fieschi C et al. Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients. Haematologica 2018; 103(8):  1278-1287.