6th Management Committee Meeting
4th Working Groups Meeting
16-17 March 2023, The Hague, The Netherlands
Virtual/Hybrid event, Time Zone: CET
(ZOOM link will be sent via email prior to the meeting)
Local Organizer: the European Hematology Association
Venue: the EHA Executive Offices , Koninginnegracht 12b, 2514 AA
the Hague/ the Netherlands
Note: the link to connect online will be announced shortly before the Meeting to all invited participants
Day 1
March 16th, 2023
13:00 - 14:30 MANAGEMENT COMMITTEE MEETING (virtual/hybrid)
Attendance by MC Members
14:30 - 14:45 Coffee Break
14:45 - 17:30 WORKING GROUPS MEETING- PART I (hybrid)
Chairs: H.Papadaki, C.Dufour
Attendance by all WG Members.
14:45 - 16:00 WG5 session: CNP Patient Registries and Biobanking
[WG5 Leader/Co-Leader: C.Zeidler, K.Stamatopoulos]
Discussion topics:
- Continuation of the guidelines on Chronic Neutropenias/ Treatment guidelines.
- How national databases can cooperate with the SCNIR in the future.
16:00 - 16:30 SCNIR EUROPE/USA session
[Panel: D.Dale, P.Newburger, A.Shimamura, J.Skokowa, K.Welte, C.Zeidler]*
16:30 - 16:50 Young EuNet-INNOCHRON session
[Chair/Co-Chair: M. Klimiankou, V. Bezzerri]
16:50 - 17:30 Any Other Business
END OF DAY 1
Day 2
March 17th, 2023
09:00 - 16:00 WORKING GROUPS MEETING- PART II (hybrid)
Chairs: H.Papadaki, C.Dufour
Attendance by all WG Members.
09:00 - 10:15 WG1 session: Congenital Neutropenias
[WG1 Leader/Co-Leader: A. Warren, K. Welte]
- “Update on the phenotype-genotype correlation in CN and CyN patients with ELANE mutations” (K.Welte, I.Tesakov)
- “Pathomechanism of neutropenia in CN patients downstream of JAGN1 mutations” (J. Skokowa)
- “Lessons from somatic leukaemia panel analysis of patients with inherited neutropenias” (M.Klimiankou)
10:15 - 11:30 WG2 session: Acquired Neutropenias
[WG2 Leader/Co-Leader: P. Höglund, J. Bux, F. Fioredda]
- “Anti-neutrophil antibody detection via GIFT vs Luminex and potential of anti-neutrophil antibodies to trigger macrophage phagocytosis.” (P.Norris)
- “Immunological pattern of newly diagnosed autoimmune and idiopathic neutropenia vs non remitting ones: are there any anticipatory signs of chronicity?” (MC. Giarratana, F.Fioredda)
- “On the difference (if any) between adults with idiopathic or autoimmune neutropenias, findings form the Stockholm Neutropenia Study Group” (J.Palmblad)
- “Whole Exome Sequencing in Chronic Idiopathic Neutropenia cases” (G.Tsaknakis, Alice Grossi)
11:30 - 11:45 Coffee Break
11:45 - 13:00 WG3 session: Mechanisms of Leukaemic Evolution
[WG3 Leader/Co-Leader: I. Touw, C. Mecucci]
- “A new genetic immunodeficiency syndrome characterized by mosaic tetraploidy and severe neutropenia caused by autosomal dominant mutations in LCP1 in unrelated pedigrees.” (A.Aalbers)
- “ADA2 Deficiency: A Case Study in a Rare Condition” (A.Pierini)
13:00 - 14:15 WG4 session: Investigation of Targets for Novel Therapies
[WG4 Leader/Co-Leader: J.Skokowa, J.Cichy]
- “SPLI (Secretory Leukocyte Protease Inhibitor) in pathophysiology of neutrophils” (J.Cichy)
- “Congenital neutropenia syndrome associated with CXCR2 mutations” (M.Klimiankou, G.Tsaknakis)
- “Successful application of the drug repurposing approach to iPSC model of congenital neutropenia.”(J.Skokowa)
- “An update on clinical trials of mavorixafor for treatment of neutropenia and WHIM syndrome” (K. Zmajkovicova)
14:15 - 15:00 Light Lunch Break
15:00 - 16:00 Discussion all Working Groups
16:00 Closing remarks
END of MEETING
|
Speakers/Chairs * |
Affiliation |
City |
Country |
|
Anna Aalbers |
Department of Hematology, Erasmus University Medical Center |
Rotterdam |
Netherlands |
|
Valentino Bezzerri |
Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata di Verona |
Verona |
Italy |
|
Juergen Bux |
Ruhr University Bochum |
Bochum |
Germany |
|
Joanna Cichy |
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University |
Krakow |
Poland |
|
David Dale |
University of Washington |
Seattle Washington |
USA |
|
Carlo Dufour |
Hematology Unit, IRCCS Istituto Giannina Gaslini, Children Research Hospital |
Genova |
Italy |
|
Francesca Fioredda |
Hematology Unit, IRCCS Istituto Giannina Gaslini, Children Research Hospital |
Genova |
Italy |
|
Maria Carla Giarratana |
Hematology Unit, IRCCS Istituto Giannina Gaslini, Children Research Hospital |
Genova |
Italy |
|
Alice Grossi |
Hematology Unit, IRCCS Istituto Giannina Gaslini, Children Research Hospital |
Genova |
Italy |
|
Petter Höglund |
Center for Hematology and Regenerative Medicine (HERM), Departments of Hematology and Clinical Immunology and Transfusion Medicine , Karolinska University Hospital Huddinge |
Stockholm |
Sweden |
|
Maksim Klimiankou |
Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen |
Tübingen |
Germany |
|
Cristina Mecucci |
Hematology and Bone Marrow Transplantation Unit, Department of Medicine, Molecular Medicine Laboratory, University of Perugia |
Perugia |
Italy |
|
Peter Newburger |
Departments of Pediatrics and Molecular, Cell and Cancer Biology, University of Massachusetts Medical School |
Worcester, Massachusetts |
USA |
|
Peter Norris |
Karolinska Institutet |
Stockholm |
Sweden |
|
Jan Palmblad |
Department of Hematology, Karolinska University Hospital Huddinge |
Stockholm |
Sweden |
|
Helen Papadaki |
Haemopoiesis Research Lab University of Crete / Haemopoiesis Department University Hospital of Heraklion |
Heraklion |
Greece |
|
Antonio Pierini |
Department of Medicine, University of Perugia |
Perugia |
Italy |
|
Akiko Shimamura |
Boston Children's Hospital, Boston, MA |
Boston, Massachusetts |
USA |
|
Julia Skokowa |
Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen |
Tübingen |
Germany |
|
Kostas Stamatopoulos |
Centre for Research and Technology Hellas (CERTH) |
Thessaloniki |
Greece |
|
Ivan Tesakov |
Department of Oncology, Hematology, Immunology, and Rheumatology, University Hospital Tuebingen |
Tübingen |
Germany |
|
Ivo Touw |
Department of Hematology, Erasmus University Medical Center |
Rotterdam |
Netherlands |
|
Grigorios Tsaknakis |
Haemopoiesis Research Lab, University of Crete |
Heraklion |
Greece |
|
Alan Warren |
Cambridge Institute for Medical Research ; Department of Haematology, University of Cambridge; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, |
Cambridge |
UK |
|
Karl Welte |
University Children's Hospital Tuebingen |
Tübingen |
Germany |
|
Cornelia Zeidler |
Hannover Medical School; Director, SCNIR-European branch |
Hannover |
Germany |
|
Katarina Zmajkovicova |
X4 Pharmaceuticals (Austria) GmbH (Group Leader) |
Vienna |
Austria |
*in alphabetical order