My current research interest in neutropenia is focused mainly on characyerization of genetic background , of geno-phenotype correlation and on pathogenic mechanisms of either primary and secondary autoimmune neutropenias with special attention to those forms that may mimic a marrow failure status but turn out to sustained by immune dysregulations.
We are also interestes in investigating pathogenic involvement of pro-apoptotc intacellular pathways.
Involved in immune neutropenias. Since the Unit I chair is the seat of the Italian Registries of Neutropenia and of ALPS( Auoimmune Lympho proliferative Syndrome) we also perform the genetic/phenotypic diagnosis and clinical caractherization of these diseases. Finally we conduct inteventional clinica trials on Peghilated G-CSF in neutropenias and on T Cell Depleted Stem Cell Transplantaion in neutropenias and bone marrow failure patients.
Clinical Pediatric Haematology with special experience in patients with constitutional and acquired neutropenias and bone marrow failure disorders (Acquired Aplastic Anemia, Fanconi Anemia, Telomere Biology Diseases)