Dr Grigorios TSAKNAKIS

Contact Information

Dr Grigorios Tsaknakis
University of Crete, School of Medicine
Address:  Haemopoiesis Research Laboratory, University of Crete, Medical School, 5D11 Wing, 71500 Voutes, Heraklion, Crete, Greece

Email: g.tsaknakis@uoc.gr
Tel:    +302810394637

Current research interests

My current research interest is focused mainly on profiling the molecular landscape of patients with myeloid malignancies. More specifically I am interested in mutational analysis of genes that are recurrently mutated in myeloid malignancies in adult patients with idiopathic neutropenias of undetermined significance in order to estimate the predictive significance of somatic mutations for identifying individuals with a myeloid neoplasm or with an increased risk of developing these malignancies.

Clinical Expertise related to EuNet-INNOCHRON

Clinical Laboratory sciences with special experience in stem cell cultures from patients with myeloid malignancies. 

Laboratory Epertise related to EuNet-INNOCHRON

  • Targeted NGS profiling of patients with myeloid malignancies (acute leukemias, MDS, myeloproliferative disorders)
  • Targeted NGS profiling of patients with idiopathic neutropenias of undetermined significance
  • iPSC cultures
  • Cell cultures of HSCs, BM MSCs 
  • Real-time PCR

Recent publications related to Eunet-INNOCHRON

  • Roubelakis MG*, Tsaknakis G*, Pappa KI, Anagnou NP, Watt SM. Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One. 2013;8(1):e54747. 
  • Athanassopoulos A*, Tsaknakis G*, Newey SE, Harris AL, Kean J, Tyler MJ and Watt SM. Microvessel Networks in Pre-formed in Artificial Clinical Grade Dermal Substitutes in vitro using Cells from Haematopoietic Tissues. Burns. 2012; 38(5):691-701.
  • Zhou B*, Tsaknakis G*, Coldwell KE, Khoo CP, Roubelakis MG, Chang C, Pepperell E, Watt SM. A Novel Function for the Haemopoietic Supportive Murine Bone Marrow MS-5 Mesenchymal Stromal Cell Line in Promoting Human Vasculogenesis and Angiogenesis. Br J Haematol. 2012; 175(3);299-311. 
  • Walker NG, Mistry A, Smith LE, Eves P, Forster S, Tsaknakis G, Watt S, Mac Neil S. A Chemically-defined Carrier for the Delivery of Human Mesenchymal Stem/Stromal Cells to Skin Wounds. Tissue Eng Part C Methods. 2011; 18(2):143-155.