Prof Alan WARREN

Contact Information

Alan J Warren
University of Cambridge, Departent of Haematology
Address: Cambridge Institute for Medical Research (CIMR)
Hills Road

TEL:   +44 (0)1223 748 488

Current research interests

We aim to eludcidate the molecular mechanisms of human ribosome assembly to understand how mutations that target this process cause neutropenia and increased propensity to develop MDS and AML. A particular focus of our work is the inherited bone marrow failure disorder Shwachman-Diamond syndrome.

Clinical Expertise related to EuNet-INNOCHRON

Clinical Haematology with expertise in inherited bone marrow failure disorders (Shwachman-Diamond syndrome, Diamond-Blackfan anaemia, Dyskeratosis congenita), aplastic anaemia, congenital neutropenia, MDS and AML.

Laboratory Epertise related to EuNet-INNOCHRON

  • Protein expression,
  • Biochemistry,
  • Quantifying global cellular protein translation rates 

Recent publications related to Eunet-INNOCHRON

  • Tan S, Kermasson L, Hoslin A, Jaako P, Faille A, Acevedo-Arenzana A, Lengline E, Ranta D, Poirée, M, Fenneteau O, Ducou le Pointe H, Fumagalli S, Beaupain B, Nitschke P, Bôle-Feysot C, de Villartay J-P, Bellanné-Chantelot C, Donadieu J, Kannengiesser C, Warren AJ*, and Revy P*. EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome. Blood 2019:blood.2018893404; doi: *Joint corresponding authors. PMID: 31151987
  • Kargas V*, Castro-Hartmann P*, Escudero-Urquijo N, Dent K, Carvalho M, Sailer C, Zisser G, Hilcenko C, Freund S, Wagstaff J, Andreeva A, Faille A, Chen E, Stengel F, Bergler H, Warren AJ. Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. eLife 2019;8:e44904 doi: 10.7554/eLife.44904. PMID: 31115337
  • Zyryanova AF*, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ* and Ron D*. Binding of the integrated stress response inhibitor ISRIB reveals a regulatory site in the nucleotide exchange factor, eIF2B. Science 2018 Mar 30;359 (6383):1533-1536. doi: 10.1126/science.aar5129. *Joint corresponding authors. PMID: 29599245
  • Warren AJ. Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome. Adv Biol Regul. (2018) Jan; 67:109-127. doi: 10.1016/j.jbior.2017.09.002. Epub 2017 Sep 6. PMID: 28942353