Alan J Warren
University of Cambridge, Departent of Haematology
Address: Cambridge Institute for Medical Research (CIMR)
Hills Road
Cambridge
CB2 0XY

Email: ajw1000@cam.ac.uk
TEL:   +44 (0)1223 748 488

We aim to eludcidate the molecular mechanisms of human ribosome assembly to understand how mutations that target this process cause neutropenia and increased propensity to develop MDS and AML. A particular focus of our work is the inherited bone marrow failure disorder Shwachman-Diamond syndrome.

Clinical Haematology with expertise in inherited bone marrow failure disorders (Shwachman-Diamond syndrome, Diamond-Blackfan anaemia, Dyskeratosis congenita), aplastic anaemia, congenital neutropenia, MDS and AML.

• Protein expression,
• Biochemistry,
• Quantifying global cellular protein translation rates 

• Tan S, Kermasson L, Hoslin A, Jaako P, Faille A, Acevedo-Arenzana A, Lengline E, Ranta D, Poirée, M, Fenneteau O, Ducou le Pointe H, Fumagalli S, Beaupain B, Nitschke P, Bôle-Feysot C, de Villartay J-P, Bellanné-Chantelot C, Donadieu J, Kannengiesser C, Warren AJ*, and Revy P*. EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome. Blood 2019:blood.2018893404; doi: https://doi.org/10.1182/blood.2018893404. *Joint corresponding authors. PMID: 31151987
• Kargas V*, Castro-Hartmann P*, Escudero-Urquijo N, Dent K, Carvalho M, Sailer C, Zisser G, Hilcenko C, Freund S, Wagstaff J, Andreeva A, Faille A, Chen E, Stengel F, Bergler H, Warren AJ. Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. eLife 2019;8:e44904 doi: 10.7554/eLife.44904. PMID: 31115337
• Zyryanova AF*, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ* and Ron D*. Binding of the integrated stress response inhibitor ISRIB reveals a regulatory site in the nucleotide exchange factor, eIF2B. Science 2018 Mar 30;359 (6383):1533-1536. doi: 10.1126/science.aar5129. *Joint corresponding authors. PMID: 29599245
• Warren AJ. Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome. Adv Biol Regul. (2018) Jan; 67:109-127. doi: 10.1016/j.jbior.2017.09.002. Epub 2017 Sep 6. PMID: 28942353