Prof Helen Papadaki
University of Crete, School of Medicine
Address: University of Crete, Medical School, 5D11 Wing
& University Hospital of Heraklion, 71500 Voutes, Heraklion, Crete, Greece

Email: e.papadaki@uoc.gr
Tel:    +302810394637

My current research interest is focused mainly on the pathogenesis of chronic neutropenia in adults. I am specifically interested in the identification of cellular, molecular, immune and genetic mechanisms underlying different types of chronic neutropenias, the differential diagnosis of the benign from the pre-malignant cases and the early recognition of malignant evolution based on longitudinal follow-up of these patients. The role of the BM microenvironment in the pathogenesis of chronic neutropenia and MDS is also one of my main research interests. 

Clinical Haematology with special experience in patients with chronic neutropenia and myeloid malignancies (MDS/AML). 

• Flow cytometry of PB and BM
• BM cultures of HSCs 
• Studies of BM MSCs
• Real-time PCR
• Anti-neutrophil antibody screening usisng GAT-GIFT

• Bizymi N, Bjelica S, Kittang AO, Mojsilovic S, Velegraki M, Pontikoglou C, Roussel M, Ersvær E, Santibañez JF, Lipoldová M, Papadaki HA. Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets. Hemasphere. 2019 Jan 28;3(1):e168. 
  
  
• Bizymi N, Velegraki M, Damianaki A, Koutala H, Papadaki HA. Altered Monocyte Subsets in Patients with Chronic Idiopathic Neutropenia. J Clin Immunol. 2019 Nov;39(8):852-854.
  
  
• Mavroudi I, Eliopoulos AG, Pontikoglou C, Pyrovolaki K, Damianaki A, Koutala H, Zervou MI, Ximeri M, Mastrodemou S, Kanellou P, Goulielmos GN, Papadaki HA. Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. Clin Immunol. 2017 Oct;183:75-81. 
  
  
• Mastrodemou S, Stalika E, Vardi A, Gemenetzi K, Spanoudakis M, Karypidou M, Mavroudi I, Hadzidimitriou A, Stavropoulos-Giokas C, Papadaki HA, Stamatopoulos K. Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors.Leuk Lymphoma. 2017 Dec;58(12):2926-2933.