Prof dr Ivo P. Touw
Department of Hematology, Erasmus University Medical Center 
Address: Erasmus MC Cancer Institute, Rm Ee- 1330c Wytemaweg 80, 3015CN Rotterdam, The Netherlands 

Email: i.touw@erasmusmc.nl
Tel:    +31 10 704 3837 

Major research interests include the molecular and cellular aspects of acute myeloid leukemia and leukemia predisposition syndromes in both children and adults, specifically severe congenital neutropenia (SCN), with emphasis on signaling mechanisms controlling myeloid differentiation. This includes the functional consequence of nonsense mutations in the receptor for G-CSF (CSF3R) and their leukemia-predisposing nature in SCN, G-CSF receptor signaling function in relation to endocytotic trafficking and dissection of critical mechanisms involved herein, and the discovery of (epi)genetic defects associated with leukemic progression.   

N/A

• Mouse models 
• BM cultures of HSCs 
• Next generation sequencing
• Genome editing
• Induced pluripotent stem cell models

• Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K. Severe congenital neutropenias. Nat. Rev. Dis Primers 2017, Jun 8;3:17032
• Beekman R, Valkhof MG, Sanders MA, van Strien PM, Haanstra JR, Broeders L, Geertsma-Kleinekoort WM, Veerman AJ, Valk PJ, Verhaak RG, Löwenberg B, Touw IP. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood. 2012 May 31;119(22):5071-7.
• Touw IP. Game of clones: the genomic evolution of severe congenital neutropenia. Hematology Am Soc Hematol Educ Program. 2015 Dec 5;2015(1):1-7.
• Beekman R, Valkhof M, van Strien P, Valk P, Touw IP. Prevalence of a new auto-activating colony stimulating factor 3 receptor mutation (CSF3R-T595I) in acute myeloid leukemia and severe congenital neutropenia. Haematologica. 2013 May;98(5):e62-3.