Prof Joanna CICHY

Contact Information

Prof. Joanna Cichy, PhD
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
Address: Gronostajowa 7 St., 30-387 Krakow, Poland


Current research interests

My long-standing interest is to understand proteolytic regulatory mechanisms that orchestrate immune cell responses. These include regulation mediated by serine proteases (such as neutrophil elastase) and  inhibitors of serine proteases, including secretory leukocyte proteinase inhibitor-(SLPI) and serpins.  

Clinical Expertise related to EuNet-INNOCHRON

Collaboration with clinicists on different aspects of neutrophil activation, mostly in pathophysiology of cutaneous inflammatory diseases.

Laboratory Epertise related to EuNet-INNOCHRON

  • Inhibitors of serine proteases (including SLPI) in regulation of neutrophil function. 
  • Elastase/eslatase inhibitors in the context of neutrophil’s diversity. 

Recent publications related to Eunet-INNOCHRON

  • Majchrzak-Gorecka M, Majewski P, Grygier B, Murzyn K, Cichy J. Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response. Cytokine Growth Factor Rev. 2016 Apr;28:79-93.  Review.
  • Majewski P, Majchrzak-Gorecka M, Grygier B, Skrzeczynska-Moncznik J, Osiecka O, Cichy J. Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps. Front Immunol. 2016 Jun 30;7:261. Review.
  • Zabieglo K, Majewski P, Majchrzak-Gorecka M, Wlodarczyk A, Grygier B, Zegar A, Kapinska-Mrowiecka M, Naskalska A, Pyrc K, Dubin A, Wahl SM, Cichy J.The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps.J Leukoc Biol. 2015 Jul;98(1):99-106
  • Skrzeczynska-Moncznik J, Wlodarczyk A, Zabieglo K, Kapinska-Mrowiecka M, Marewicz E, Dubin A, Potempa J, Cichy J. Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis. J Immunol. 2012 189(4):1611-7.