Prof Julia SKOKOWA


Contact Information

Prof. Dr. med. Julia Skokowa, Ph.D
University Hospital Tuebingen, Germany
Adress: Otfried-Mueller Str. 10, 
72076 Tuebingen, Germany

Email: julia.skokowa@med.uni-tuebingen.de


Current research interests

My main research interests are: 

  1. the understanding of the molecular pathomechanisms of severe congenital neutropenia and leukemia;
  2. establishment of the experimental in vitro and in vivo models of neutropenia, pre-leukemia and leukemia;
  3. identification of novel therapeutic approaches for neutropenia, pre-keulemia and leukemia;
  4. gene therapy of neutropenia;
  5. genetic diagnostics of neutropenia  


Clinical Expertise related to EuNet-INNOCHRON

Pediatric/Internal Hematology and Oncology, pre-leukemia bone marrow failure syndromes, leukemia


Laboratory Epertise related to EuNet-INNOCHRON

  • Neutropenia and leukemia modeling using patients-derived iPSCs and CRISPR/Cas9 gene editing
  • Zebrafish and mouse models of congenital neutropenia
  • High-throughput drug screening
  • Gene mutations in congenital neutropenia patients
  • Myeloid differentiation of primary HSCs and iPSCs
  • CRISPR/Cas9-mediated correction of CN-associated gene mutations in primary HSCs and iPSCs

Recent publications related to Eunet-INNOCHRON

  • Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica. 2019: haematol.2019.221804. 
  • Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K. Severe congenital neutropenias. Nat Rev Dis Primers. 2017;3:17032
  • Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Göhring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis. Blood. 2014;123:2229-37.
  • Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J. (2014) A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood; 123:1239-49.