Prof. Dr. med. Karl Welte
Seniorprofessor of the University Tuebingen, Germany
Adress: University Children Hospital Tuebingen, Hoppe-Seyler-Str. 1
72076 Tuebingen, Germany

Email: Karl.Welte@med.uni-tuebingen.de 

• Molecular pathomechanisms of bone marrow failure syndromes in children
• Molecular mechanisms of childhood leukemias
• Treatment of children with congenital neutropenias 
• Gene therapy in congenital bone marrow failure syndromes

Clinical Pediatric Hematology and Oncology, especially childhood bone marrow failure dyndromes and leukemias

• Bone marrow cultures,
• hematopietic stem cell research, 
• Cytokine activities

• CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J. Haematologica. 2019: haematol.2019.221804. 
• Severe congenital neutropenias. Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K. Nat Rev Dis Primers. 2017;3:17032
• Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis. Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Göhring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Blood. 2014;123:2229-37.