Contact Information

Prof. Kim De Keersmaecker
Department of Oncology, 
KU Leuven, Belgium
Address: Campus Gasthuisberg, O&N1 Herestraat 49, box 603 
3000 Leuven, Belgium

Tel:    +3216373167

Current research interests

I am interested in somatic and congenital mutations in ribosomal protein and biogenesis genes in adults and children. I study the molecular biological mechanisms by which these lesions induce anemia followed by an elevated risk to develop leukemia and solid cancers. 

Clinical Expertise related to EuNet-INNOCHRON


Laboratory Expertise related to EuNet-INNOCHRON

Molecular biological analysis of the cellular consequences of ribosomal defects using state-of-the-art proteomics and genomics technologies in cell and mouse models. 

Recent publications related to Eunet-INNOCHRON

  • Sulima, S.O., Kampen, K.R., Vereecke, S., Pepe, D., Fancello, L., Verbeeck, J., Dinman, J.D., De Keersmaecker, K. (2019). Ribosomal Lesions Promote Oncogenic Mutagenesis. Cancer Research, 79 (2), 320-327. 
  • Girardi, T., Vereecke, S., Sulima, S.O., Khan, Y., Fancello, L, Briggs, J.W., Schwab, C., Op de Beeck, J., Verbeeck, J., Royaert, J, Geerdens, E., Vicente, C., Bornschein, S., Harrison, C.J., Meijerink, J.P., Cools, J., Dinman, J.D., Kampen, K.R., De Keersmaecker, K. (2018). The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling Leukemia, 32(3), 809-819.
  • Kampen, K.R., Sulima, S.O., Verbelen, B., Girardi, T., Vereecke, S., Rinaldi, J., Verbeeck, J., Op de Beeck, J., Uyttebroeck, A., Meijerink, J.P.P., Moorman, A.V., Harrison, C.J., Spincemaille, P., Cools, J., Cassiman, D., Fendt, S.M., Vermeersch, P., De Keersmaecker, K. (2018). The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL. Leukemia 33 (2), 319-332
  • De Keersmaecker K, Sulima SO, Dinman JD. Ribosomopathies and the paradox of cellular hypo- to hyperproliferation. Blood. 2015;125(9):1377–1382.